Clinical Utility of Unbiased Metagenomic Next-Generation Sequencing in Diagnosis of Acute Infectious Diseases: A Prospective Case Series
نویسندگان
چکیده
103. Clinical Utility of Unbiased Metagenomic Next-Generation Sequencing in Diagnosis of Acute Infectious Diseases: A Prospective Case Series Samia N. Naccache, PhD; Alex Greninger, BS; Erik Samayoa, BS; Steve Miller, MD, PhD; Charles Y. Chiu, MD, PhD; Laboratory Medicine, University of California, San Francisco, San Francisco, California; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco; University of California, San Francisco, San Francisco, California; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California; Laboratory Medicine and Medicine/Infectious Diseases, University of California, San Francisco, San Francisco, California
منابع مشابه
Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing
Metagenomic next-generation sequencing (NGS) was used to diagnose an unusual and fatal case of progressive encephalitis in an immunocompromised adult presenting at disease onset as bilateral hearing loss. The sequencing and confirmatory studies revealed neuroinvasive infection of the brain by an astrovirus belonging to a recently discovered VA/HMO clade.
متن کاملNeurobrucellosis: Unexpected Answer From Metagenomic Next-Generation Sequencing.
A diagnosis of brucellosis can be difficult because routine culture and serological methods exhibit variable sensitivity and specificity. We present the use of a metagenomic next- generation sequencing assay to diagnose a case of neurobrucellosis from cerebrospinal fluid, resulting in the institution of appropriate antibiotic treatment and a favorable clinical outcome.
متن کاملDiagnosis of Fatal Human Case of St. Louis Encephalitis Virus Infection by Metagenomic Sequencing, California, 2016
We used unbiased metagenomic next-generation sequencing to diagnose a fatal case of meningoencephalitis caused by St. Louis encephalitis virus in a patient from California in September 2016. This case is associated with the recent 2015-2016 reemergence of this virus in the southwestern United States.
متن کاملHepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing
Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation.
متن کاملStrategies and Clinical Applications of Next Generation Sequencing
Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2015